Endocrine Abstracts

Multiple endocrine neoplasia type 1 (MEN1) and MEN) are distinct clinical and genetic entities.This talk will cover the key clinical features and surveillance strategies for each of these conditions....

We are a presenting a 57 year old male victim of recurrent metastatic melanoma who was treated surgically in 2015 by wide local excision together with right axillary dissection for axillary nodal spread. He re-presented to dermatology clinic in December 2018 with skin lesion that was histologically proven to be a BRAF-mutant malignant melanoma. CT scans at that time showed spread to mediastinal and hilar nodes. Oncology team decided to commence Iplimumab/Nivolumab combination ...

Regulatory peptides are known to have a role in tumour growth. Local peptide concentrations will be affected by their proteolytic release from precursors, together with the rate of their proteolytic degradation. In this study three inhibitors of proteolysis were examined, Captopril, an ACE inhibitor, Thiorphan an inhibitor of Neutral Endopeptidase and Phosphoramidon which inhibits both Neutral Endopeptidase and also Endothelin Converting Enzyme (ECE). The effect of these inhib...

Case History: A 71-year-old man with well controlled hypertension and left eye blindness due to congenital toxoplasma chorioretinitis presented to his GP with worsening headache. Initial CT head revealed a massive left parasellar lesion (32*25*36 mm) with suprasellar extension. Gadolinium-enhanced MRI revealed large cystic sellar mass, marked chiasmal compression and total encasement of Left carotid artery. 48 hours after MRI he was admitted acute severe right abdominal pain. ...

A 72 year old gentleman with an eight month history of chronic, episodic diarrhoea had been investigated as an out-patient. Colonoscopy and biopsies, barium meal and follow-through, coeliac screen and thyroid function tests were all normal. He subsequently presented with an acute deterioration in diarrhoea, and severe hypokalaemia, acute renal failure and a profound metabolic acidosis. Haemofiltration and aggressive fluid management were required to compensate for gastro-intes...

Adrenal incidentalomata are a common finding on cross-sectional imaging of the abdomen. Further assessment is required to differentiate benign adrenal masses from adrenocortical carcinomas and hormone-secreting tumours. Phaeochromocytomas are rare catecholamine-secreting tumours arising from chromaffin cells of the adrenal medulla. They classically present with symptoms and signs of catecholamine excess including headache, sweating, hypertension and tachycardia. However, with ...

The present study was carried out to investigate the reproductive toxicity of butyl benzyl phthalate (BBzP) on semen characteristics, hormones levels (testosterone, LH and FSH), testicular lipid peroxidation and antioxidants enzymes and histological changes in testes in male rabbits for 12 weeks. The flaxseed lignan and its mammalian metabolites have been reported to exert protective effects against diet-related chronic diseases through a variety of mechanisms including phytoe...

Background: GH therapy in adolescents with childhood onset GH deficiency (CO-GHD) is often necessary to prevent adult GHD syndrome and requires a re-evaluation of the GH axis on attainment of final height. Not all individuals with CO-GHD remain GH deficient and re-evaluation is required to confirm or refute adult GHD.Aim: Review the care received by young adults diagnosed with CO-GHD.Design: Retrospective review of young adults wit...

Children with congenital hypothyroidism (CH) due to anatomical defects (AD) have different thyroid hormone levels at presentation from those with dyshormonogenesis (DH). We set out to explore these differences at initial presentation and at follow up. We also compared calcitonin levels and growth in these subjects with healthy controls. Data for the CH children were collected from hospital notes for birth weight, gestation, sex, initial laboratory thyroid function, starting do...

Serum of infertile males and that of proven fathers (n=717) was analysed for the measurement of sperm concentration, serum LH, FSH and testosterone. Earlier, when classified on the basis of sperm count, 13% males turned out to be azoospermic, 15% oligozoospermic, 0.025% polyzoospermic and 42% normozoospermic in a five year analysis. Oligozoospermic subjects were further classified as mild, moderate and severe oligozoospermic. Hormonal analysis indicated normal levels of LH and...